Improving protein succinylation sites

Author: vjga

August undefined, 2024

WebFeb 4, 2024 · Succinylation is achieved by non-enzymatic processes or by a series of enzymes [like p300, lysine acetyltransferase 2A (KAT2A)] that transfer the succinyl groups from succinyl-coenzyme A (CoA) to the specific lysine, modulating protein function in various physiological processes [ 1 ]. WebOct 21, 2024 · Succinylation can improve the solubility of milk protein concentrate and sodium caseinate. The result of differential calorimetry scanning illustrated that the …

pSuc-Lys: Predict lysine succinylation sites in proteins with …

WebThe succinylation modification of protein participates in the regulation of a variety of cellular processes. Identification of modified substrates with precise sites is the basis for … WebThe potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da), it is expected to lead to more significant changes in protein structure and … chin\u0027s 2k

Dynamic Responses of Barley Root Succinyl-Proteome to Short …

WebOct 8, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. WebSuccinylation, which is among the more recently discovered PTMs, is comparatively unique 3. Like methyla-tion, acetylation or ubiquitination, succinylation also occurs on lysine … WebApr 23, 2024 · Using an independent test set of experimentally identified succinylation sites, our method achieved efficiency scores of 79%, 68.7% and 0.48 for sensitivity, specificity … granola with flax seed and pumpkin seeds

Incorporating convolutional neural networks and sequence graph ...

Core-predominant gut fungus Kazachstania slooffiae promotes …

WebMar 22, 2024 · Purified KGDHC can succinylate and modify the activity of multiple proteins including albumin and other enzymes of the TCA cycle including the pyruvate dehydrogenase complex (PDHC) and ICDH. The greater effectiveness of KGDHC than succinyl CoA suggests that the catalysis owing to the E2k succinyltransferase is … WebDec 27, 2024 · Locating succinylation sites using experimental methods, such as mass spectrometry is very laborious. Hence, computational methods are favored using machine … chin\u0027s 2mWebApr 7, 2016 · A new predictor named pSuc-FFSEA, which can predict succinylation sites in protein sequences by feature fusion and stacking ensemble algorithm is developed, which showed excellent robustness and performed better than the previous prediction tools. 2 PDF granola with honey and maple syrup

"WebLMSuccSite: Improving Protein Succinylation Sites Prediction Using Embeddings from Protein Language Model Figures Additional Declarations " - Improving protein succinylation sites

Improving protein succinylation sites

[2201.11215] Predicting Succinylation Sites in Proteins with …

WebMar 31, 2024 · Barley (Hordeum vulgare L.)—a major cereal crop—has low Pi demand, which is a distinct advantage for studying the tolerance mechanisms of phosphorus deficiency. We surveyed dynamic protein succinylation events in barley roots in response to and recovery from Pi starvation by firstly evaluating the impact of Pi starvation in a Pi-tolerant (GN121) … WebDownload scientific diagram Two Sample Logos of the succinylation lysine sites compared to unlabeled sites. Different color of symbles represents different physical and chemical properties ...

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WebFeb 23, 2024 · K. slooffiae decreased intestinal epithelial lysine succinylation levels, and these proteins were especially enriched in the glycolysis pathway. We demonstrated that K. slooffiae promoted intestinal epithelial glycolysis by decreasing lysine succinylation by activating sirtuin 5 (SIRT5). WebNov 23, 2024 · The increase of protein succinylation in zebrafish appeared to be larger in response to sucla2 deficiency than with loss of sirt5, confirming what was predicted by …

WebFeb 1, 2024 · Of all succinylation proteins identified, 48.1% (312/649) possessed only one modified site, 21.4% (139/649) had two succinylated peptide sites, 9.9% (64/649) contained three sites, and 1.2% (8/649) of modified proteins have 10 or more sites (see Figure 1A ). The average degree of succinylation sites per protein was 2.4 (1557/649). WebIdentifying of post-translational modifications (PTM) is crucial in the study of computational proteomics, cell biology, pathogenesis, and drug development due to its role in many bio-molecular mechanisms. Computational methods for predicting multiple PTM ...

WebAug 18, 2024 · Abstract. Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including … WebOct 1, 2024 · As mitochondria are thought to be lysine succinylation hot spots, the proteins primarily affected by succinylation can naturally be expected to be the mitochondrial ones. However, with few exceptions ( 24, 43 ), most studies on eukaryotic succinylomes were performed on whole-cell extracts.

WebProtein succinylation is a type of post-translational modification (PTM) that occurs on lysine sites and plays a key role in protein conformation regulation and cellular function control.

WebAug 11, 2024 · Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, … chin\u0027s 2iWebSuccinylation Links Metabolism to Protein Functions. Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with … chin\u0027s 2oWebFeb 12, 2024 · The original collection comprised 2,521 succinylation and 24,128 non-succinylation sites from 896 unique proteins. To avoid overestimations due to homology … chin\u0027s 2uWebLMSuccSite is likely to serve as a valuable resource for exploration of succinylation and its role in cellular physiology and disease. Protein succinylation is an important post … chin\u0027s 2sWebApr 8, 2024 · LDHA succinylation and protein levels were analysed by immunoblotting using the indicated antibodies. C K1 cells were transfected with HA-LDHA and pCDNA-GLTC (or the empty vector control) for 48 h ... chin\u0027s 2rWebFeb 10, 2024 · Encouraged by the successful application of the compression strategy on nucleotide sequences, we applied it to protein sequences. For the 2 × 20 contingency table for each position in succinylation site-containing sequences, the compression procedure is described below. Step 1: Set the initial value of r ( r is an integer) to 20. chin\u0027s 2xWebNov 11, 2024 · Succinylation is an important posttranslational modification of proteins, which plays a key role in protein conformation regulation and cellular function control. Many studies have shown that succinylation modification on protein lysine residue is closely related to the occurrence of many diseases. To understand the mechanism of … chin\u0027s 2w