Chiral bronsted acid mediated glycosylation
WebMay 15, 2015 · BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Chemistry & Biochemistry - ECPv6.0.11//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Chemistry & Biochemistry X-ORIGINAL-UR WebOct 13, 2014 · The stereochemical outcome of glycosylation reactions of 2-deoxy-sugar trichloroacetimidates promoted by chiral Brønsted acids is shown to be dependent on both the chirality of the catalyst...
Chiral bronsted acid mediated glycosylation
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WebChiral Brønsted acids are powerful organocatalysts for a great variety of asymmetric nucleophilic additions to imines (Scheme 1, eq. 1).1 In such reactions, the imine is protonated by the chiral Brønsted acid, with the resulting chiral anion directing the enan tiofacial differentiation upon attack of the nucleophile onto the iminium cation ... WebThe use of a chiral Brønsted acid catalyst for the activation of trichloroacetimidate glycosyl donors influences the stereochemical outcome of glycosylation processes in …
WebJun 14, 2024 · Based on their mechanistic studies, they proposed that chiral Brønsted acid catalyst 6 stimulated both the acceptor and the OTCA donor promoting an S N 2-type reaction with R -enantiomer of the racemic mixture of secondary alcohols to form a chiral transition state like 11, which accounts for the high 1,2- trans selectivity. SCHEME 3 … WebFeb 10, 2024 · A new type of chiral super Brønsted C–H acids, BINOL-derived phosphoryl bis((trifluoromethyl)sulfonyl) methanes (BPTMs), were developed. As compared to widely utilized BINOL-derived chiral phosphoric acids (BPAs) and N-triflyl phosphoramides (NTPAs), BPTMs displayed much higher Brønsted acidity, resulting in dramatically …
WebMar 3, 2010 · The use of a chiral Brønsted acid catalyst for the activation of trichloroacetimidate glycosyl donors has been demonstrated for the first time. In toluene … WebThe stereochemical outcome of glycosylation reactions of 2-deoxy-sugar trichloroacetimidates promoted by chiral Brønsted acids is shown to be dependent on both the chirality of the catalyst and the configuration of the leaving group. High levels of selectivity (1:16 α:β) can be obtained with (S)-catalysts and an α-trichloroacetimidate donor.
WebFeb 26, 2016 · A new member of the recently developed class of chiral confined Brønsted acids finally enables this elusive transformation with excellent selectivity and scope, and illustrates the general difficulty of dealing with oxocarbenium ion intermediates in BrøNsted acid catalysis. 108 Chiral Brønsted acids for asymmetric organocatalysis.
WebOct 11, 2024 · Chiral Brønsted acid catalysis is mostly limited to the activation of imine and carbonyl moieties. ... Qian, P.-C. & Ye, L.-W. Brønsted acid-mediated reactions of … break ins ottawa countybreakin soundtrack downloadWebOct 6, 2024 · b Chiral phosphoric acid-mediated Schmidt glycosylation through a chiral resolution-type process by Toshima and co-workers 103. c Regioselective acetalization … cost of lite and easy mealsWebNov 11, 2013 · Chiral Brønsted acid mediated glycosylation with recognition of alcohol chirality Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12131-4. doi: … cost of lithium batteries for rvWebJan 19, 2024 · With the introduction of chiral BINOL-derived N-triflyl phosphoramides in 2006, asym. Bronsted acid catalysis is no longer restricted to reactive substrates. Also certain carbonyl compds. can be activated through these stronger Bronsted acid catalysts. In dealing with sensitive substrate classes, chiral dicarboxylic acids proved of particular ... breakin songs from the 80sWebNov 1, 2008 · Chiral Bronsted Acid: Innovations and Application to Regiodivergent Glycosylations Thesis Jan 2024 Tay Rosenthal View Show abstract Organocatalytic Enantioselective Friedel‐Crafts Alkylation... cost of lithium car batteriesWebDec 15, 2013 · It was subsequently found that a combination of Brønsted acid (carboxylic acid) and Lewis acid (MgBr2) was unique in catalyzing the desired glycosylation reaction. Thus, it was concluded that the two acids act synergistically to catalyze the … breakin soundtrack list